. 2022 Aug 22;12(8):667. doi: 10.3390/bios12080667

Table 1.

Summary of AIEgen-peptide bi oprobes.

Target	Peptide	AIEgen	Responsive Site	λ_ex/λ_em (nm)	Cytotoxicity	References
Cell membrane	cRGD	TPS	α_vβ₃	356/480	no cytotoxicity	[53]
	RRRR	TPE		330/466	no cytotoxicity	[54]
	RGD-Pal-RRRR	T-MY		330/500	no cytotoxicity	[55]
	C₁₆-K(TPE)-GGGH-GFLGK-PEG₈	TPE		370/470	IC₅₀ = 0.1 mg/mL	[56]
	YCDGFYACYMDV	BP	HER2	380/520	no cytotoxicity	[57]
	YSAYPDSVPMMS	DBT	EphA2	490/642	IC₅₀ = 38.3 × 10⁻⁶ M	[58]
Nucleus	NLS	PyTPE		405/570	no cytotoxicity	[65]
Nucleus	NLS	PyTPE		405/580	no cytotoxicity	[66]
Mitochondria	HLAHLAHHLAHLAH	TPE		420/720	no cytotoxicity	[76]
Mitochondria	klaklakklaklak	PyTPA		450/620	High cytotoxicity	[77]
Lysosome	GFLG	PyTPA	CB	450/650	High cytotoxicity	[79]
	IHGHHIISVG	TPE	LAPTM4B	445/620	EC₅₀ = 3.1 μM	[80]
	ADPDQYNFSSSELGG	TPE	LAPTM4B	330/470	no cytotoxicity	[81]
	pYK(TPP)pY	TPE	ALP	400/595	IC₅₀ = 9.7 μM	[82]
Endoplasmic reticulum	KDEL	TPE		430/620	no cytotoxicity	[86]
Endoplasmic reticulum		TPA		480/653	no cytotoxicity	[87]

Abbreviations: NLS, nuclear localization signal; CB, cathepsin B; LAPTM4B, lysosomal protein transmembrane 4 beta; ALP, alkaline phosphatase.