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DPP4 structure. (A) Schematic representation of the DPP4 primary structure. The glycosylated region is shown in orange, the cysteine-rich region in green, and the catalytic region in blue. (B) Quaternary structure of the DPP4 homodimer. Metalloproteases (MMPs) are represented by a grey scissor, and after digestion, the soluble form of DPP4 (sDPP4) sheds from the membrane, releasing into biological fluids, such as the bloodstream (on the right).
