Table 1.

Patient demographics and severity of disease.

Patient	Sex	Age at Operation (months)	Phenotype	Procedure(s)	Follow-Up Duration (Months from Date of Last Procedure)	Complication
HSCR
Patient 1	Female	6	Long—proximal transverse colon	3: Ileostomy + Swenson + stoma closure	17	none
Patient 2 *	Male	6	Long—proximal descending colon	3: Ileostomy + Swenson + stoma closure	11	none
Patient 3	Male	7	Long—distal transverse colon	3: Ileostomy + Swenson + stoma closure	11	Three episodes of enterocolitis
Patient 4	Male	4	Short	3: Ileostomy + Swenson + stoma closure	12	none
Patient 5	Male	5	Long—distal descending colon	1: Swenson (no stoma)	15	Three episodes of enterocolitis
Patient 6	Male	3	Short	1: Swenson (no stoma)	10	none
Patient 7	Male	21	Short	3: Ileostomy + Swenson + stoma closure	2	none
Patient 8	Male	4	Short—rectal sigmoid (skip)	2: Colostomy + Swenson	7	Several episodes of enterocolitis
Patient 9	Male	6	Long	1: Swenson (no stoma)	6	Three episodes of enterocolitis
Patient 10	Male	3	Short	1: Swenson (no stoma)	6	Constipation
Patient 11	Female	27	Long—transverse colon	2: Colostomy + Swenson (ileostomy formed following pull-through)	-	Stoma not yet closed
Patient 12	Female	5	Long—descending colon	1: Swenson (no stoma)	13	One episode of enterocolitis
Patient 13 #	Male	27	Total colonic aganglionosis	2: Ileostomy + Duhamel	-	Stoma not yet closed
Control
Patient 1	Male	36	Neonatal necrotizing enterocolitis	2: Ileostomy + stoma closure with resection of strictured bowel	7	N/A (no follow-up)

* Patient with Waardenburg type IV. # Patient with Down syndrome. Patients 10 and 13 were excluded from tissue analysis.