Figure 1.

Heatmap of Metabolite Occurrence. A heatmap depicting the distribution of the 655 metabolites identified by the 24 PDAC papers. A hierarchical cluster of the clinical studies was performed where the row numbers correspond to the papers listed in Table 1. The numbers colored red corresponds to studies that used either plasma or serum samples. The NMR label identifies studies that used NMR whereas studies that used mass spectrometry are unlabeled. Metabolite occurrence order corresponds to the groupings in Figure 2A. The exact list and order of the metabolite names can be found in Supplemental Table S1A. For all metabolites with only a single occurrence, the metabolites are ordered alphabetically. Since most studies did not report a quantitative fold change, only a qualitative increase (red, +1) or decrease (blue, −1) in the metabolite relative to a control is indicated. Metabolites not identified in a study were assigned zero and are white.