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. 2022 Aug 11;16:879548. doi: 10.3389/fnins.2022.879548

TABLE 3.

The 24 metabolites associated with PLA2G6 mutation.

Compound Canonical pathway Mann–Whitney U-testing t-test after FDR
(q value)
Binary logistic regression ROC in PLA2G6 mutation
ROC in advanced stage
AUC P-value AUC P-value
1 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1′-rac-glycerol) 0.021 0.044 0.067 0.833 0.021 0.606
2 1-Hexadecanoyl-sn-glycero-3-phosphoethanolamine 0.009 0.015 0.06 0.875 0.009 0.439
3 1-Oleoyl-L-alpha-lysophosphatidic acid 0.005 0.016 0.04* 0.903 0.005 0.944 0.039
4 Caprylic acid Fatty acid biosynthesis 0.003 0.018 0.061 0.931 0.003 1
5 L-Palmitoylcarnitine Fatty acid degradation 0.007 0.015 0.038* 0.889 0.007 0.606
6 Oleic acid Biosynthesis of unsaturated fatty acids 0.001 0.010 0.992 1 0.001 0.944 0.039
7 PC(16:0/16:0) Arachidonic acid metabolism 0.034 0.029 0.083 0.806 0.034 0.439
8 Glycochenodeoxycholate Primary bile acid biosynthesis 0.009 0.026 0.069 0.875 0.009 0.796
9 D-Mannose Fructose and mannose metabolism 0.016 0.010 0.11 0.847 0.016 0.606
10 Glyceraldehyde 0.021 0.026 0.044* 0.833 0.021 0.606
11 D-Quinovose 0.001 0.010 0.052 0.958 0.001 0.197
12 L-Fucose Fructose and mannose metabolism 0.002 0.010 0.055 0.944 0.002 0.197
13 L-Aspartate Histidine metabolism 0.001 0.010 0.981 0.986 0.001 0.121
14 L-Glutamate Histidine metabolism 0.004 0.022 0.103 0.917 0.004 0.302
15 L-Histidine Histidine metabolism 0.012 0.015 0.067 0.861 0.012 1 0.02
16 N-Formylmethionine 0.021 0.015 0.031* 0.833 0.021 0.439
17 Arg–Ala 0.043 0.026 0.101 0.792 0.043 0.302
18 His–Glu 0.016 0.015 0.054 0.847 0.016 1
19 Hypoxanthine Purine metabolism 0.001 0.016 0.977 1 0.001 0.121
20 Xanthine Purine metabolism 0.004 0.010 0.134 0.917 0.004 0.944 0.039
21 L-Gulonic gamma-lactone Ascorbate and aldarate metabolism 0.004 0.015 0.112 0.917 0.004 0.071
22 N1-Methyl-2-pyridone-5-carboxamide Nicotinate and nicotinamide (NAM) metabolism 0.001 0.009 0.983 1 0.001 1
23 Phenol 0.083 0.044 0.239 0.083 0.796
24 Bilirubin Porphyrin and chlorophyll metabolism 0.068 0.047 0.098 0.068 0.439

Shown are the results of statistical analysis in normalized metabolite levels in PARK14 cases and matched controls, case-control comparison by the Mann–Whitney U-test, t-test after FDR (false discovery rate) correction, binary logistic regression (with age at exam and gender as covariates), and receiver operator area under the curve (ROC AUC) assessments of predictive ability in diagnosing PLA2G6 mutations and advanced stages (H&Y ≥ 3).

*p < 0.05.