Table 1.
GO analysis biological process (BP) of genes associated with cognitive dysfunction in MS.
| GO ID | Description | Count | p-Value | Genes |
|---|---|---|---|---|
| GO:0031644 | Regulation of neurological system process | 6 | 4.75 × 10−7 | BDNF, TNF, NTF4, NTF3, IL10, NGF |
| GO:0006952 | Defense response | 8 | 1.81 × 10−6 | IL17A, IFNA1, TNF, STAB1, IFNB1, IL17F, IL10, NGF |
| GO:0043523 | Regulation of neuron apoptosis | 5 | 2.36 × 10−6 | BDNF, TNF, NTF3, NEFL, NGF |
| GO:0050804 | Regulation of synaptic transmission | 5 | 1.22 × 10−5 | BDNF, TNF, NTF4, NTF3, NGF |
| GO:0009611 | Response to wounding | 7 | 1.30 × 10−5 | IL17A, TNF, STAB1, IL17F, NEFL, IL10, NGF |
| GO:0044057 | Regulation of system process | 6 | 1.50 × 10−5 | BDNF, TNF, NTF4, NTF3, IL10, NGF |
| GO:0051969 | Regulation of transmission of nerve impulse | 5 | 1.66 × 10−5 | BDNF, TNF, NTF4, NTF3, NGF |
| GO:0006954 | Inflammatory response | 6 | 1.91 × 10−5 | IL17A, TNF, STAB1, IL17F, IL10, NGF |
| GO:0009617 | Response to bacterium | 5 | 4.85 × 10−5 | TNF, STAB1, IFNB1, IL10, NGF |
| GO:0051384 | Response to glucocorticoid stimulus | 4 | 7.98 × 10−5 | TNF, NEFL, IL10, NGF |
| GO:0031960 | Response to corticosteroid stimulus | 4 | 1.03 × 10−4 | TNF, NEFL, IL10, NGF |
| GO:0042981 | Regulation of apoptosis | 7 | 1.36 × 10−4 | BDNF, TNF, NTF3, IFNB1, NEFL, IL10, NGF |
| GO:0043067 | Regulation of programmed cell death | 7 | 1.44 × 10−4 | BDNF, TNF, NTF3, IFNB1, NEFL, IL10, NGF |
| GO:0031175 | Neuron projection development | 5 | 1.45 × 10−4 | BDNF, NTF3, NTNG2, NEFL, NGF |
| GO:0010941 | Regulation of cell death | 7 | 1.47 × 10−4 | BDNF, TNF, NTF3, IFNB1, NEFL, IL10, NGF |
| GO:0051094 | Positive regulation of developmental process | 5 | 1.99 × 10−4 | BDNF, TNF, NTF3, NEFL, NGF |
| GO:0042742 | Defense response to bacterium | 4 | 2.34 × 10−4 | TNF, STAB1, IFNB1, IL10 |
| GO:0048666 | neuron development | 5 | 4.25 × 10−4 | BDNF, NTF3, NTNG2, NEFL, NGF |
| GO:0043066 | Negative regulation of apoptosis | 5 | 5.01 × 10−4 | BDNF, TNF, NEFL, IL10, NGF |
| GO:0043069 | Negative regulation of programmed cell death | 5 | 5.28 × 10−4 | BDNF, TNF, NEFL, IL10, NGF |
| GO:0060548 | Negative regulation of cell death | 5 | 5.33 × 10−4 | BDNF, TNF, NEFL, IL10, NGF |
| GO:0030030 | Cell projection organization | 5 | 5.80 × 10−4 | BDNF, NTF3, NTNG2, NEFL, NGF |