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. 2022 Aug 18;11(16):2572. doi: 10.3390/cells11162572

Figure 1.

Figure 1

(A) Female K18-hACE2 mice were either treated (Abx) or not treated (control) for 3 days before SARS-CoV-2 infection. Body weight and clinical scores were measured after infection. I. Experimental scheme of mortality: experiments were performed to evaluate percent survival up to 12 dpi. II. Experimental scheme for sample collection: mice were euthanized at 5 dpi and the organs were collected for viral load quantification. (B) Survival rate after infection with SARS-CoV-2 (n = 6). (C) Body weight changes after infection (n = 12–15). (D) Clinical scores of infected mice (n = 12–15). * p < 0.05, 2-way ANOVA. (E) Viral load determination by RT-qPCR. * p < 0.05 by Student’s t-test (n = 4–10).