Table 1.

Reported adverse events of fenfluramine and placebo groups in randomized controlled trials.

	Placebo	Fenfluramine 0.2 mg/kg/day	Fenfluramine 0.4–0.7 mg/kg/day
Reported adverse events	65–83%	78–95%	95%
Decreased appetite	5–11%	20%	36–44%
Diarrhea	7–8%	31%	18–23%
Nasopharyngitis	12–34%	10%	16–18%
Lethargy	5–9%,	10%	18–26%
Somnolence	8%	15%	10%
>7% weight loss	2–4.5%	2–13%	8–20.9%
Echocardiographic finding with trace mitral or aortic regurgitation.	7–13%	18%	23–25%
Pulmonary arterial hypertension or clinically significant signs or symptoms of cardiovascular disease	0	0	0