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. 2022 Aug 17;14(16):3975. doi: 10.3390/cancers14163975

Figure 3.

Figure 3

Immunopeptidome profiling of two TP53 mutants revealed distinct HLA-A2 and pan-HLA peptide repertoire. (A) Workflow followed for generating MHC peptidome data from the three SaOS variants; (B) Venn diagram showing number of common proteins upregulated and HLA-A2 epitopes identified in 175 mutants; (C) Venn diagram showing number of common proteins upregulated and HLA-A2 epitopes identified in 273 mutant; (D) Venn diagram showing number of common proteins upregulated and Pan-HLA epitopes identified in 175 mutants; (E) Venn diagram showing number of common proteins upregulated and Pan-HLA epitopes identified in 273 mutant; (F) protein candidates common to both mutants and both eluted fractions (eluted by BB72 and W6/32); (G) List of 34 unique protein candidates and the number of epitopes identified in each mutants in both BB72 and W6/32 fractions; (H) upset plot showing unique and common peptide epitopes identified in each mutants in HLA-A2 and Pan HLA fractions.