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. 2022 Aug 19;11(16):2592. doi: 10.3390/cells11162592

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Organisation of the domains of the three identified DNA methylases and one demethylase in Humulus lupulus. A typical C-5 cytosine-specific DNA methylase domain (PF00145) was found in CMT, DNMT, and DRM genes. In addition, CMT contains one (CHRromatin Organization MOdifier) domain (PF00385) and DNMT contains two consecutive cytosine-specific DNA methyltransferase replication foci domains (PF12047), before the two BAH domains (PF01426). The DME gene consists of two domains, an RRM in demeter (PF15628) involved in the release of methyl groups from DNA and a permuted single zf-CXXC unit (PF15629). The online tool Illustrator of Biological Sequences (IBS; http://ibs.biocuckoo.org/online.php; accessed on 8 March 2022) was used to visualize the protein domains.