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. 2022 Aug 10;11(16):2480. doi: 10.3390/cells11162480

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Evaluation of CSF NfL, MMP-2, and MMP-9 levels in neuro-COVID group. (A) Evaluation of CSF NfL levels in COVID-19 patients with severe neurological symptoms (neuro-COVID group) stratified according to ARDS development. (B) Evaluation of CSF MMP-2 levels in COVID-19 patients with neurological symptoms (neuro-COVID group) stratified according to ARDS development. (C) Evaluation of CSF MMP-9 levels in COVID-19 patients with neurological symptoms (neuro-COVID group) stratified according to ARDS development. Horizontal lines represent medians. Neuro-COVID group: COVID-19 patients with severe neurological symptoms; NfL: neurofilament light chain; HD: healthy donors; ARDS: acute respiratory distress syndrome; CSF: cerebrospinal fluid; MMP-2: matrix metalloprotease-2; MMP-9: matrix metalloprotease-9; OD: optical density. *: 0.01 < p < 0.05.