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. 2022 Aug 17;11(16):2560. doi: 10.3390/cells11162560

Figure 4.

Figure 4

MaR1 protects from ferroptosis-mediated impairment of osteogenic differentiation of osteoblasts by modulating NRF2 signaling in T2DOP. (A) EdU staining was used to assess cell survival. Red, EdU-positive nuclei; blue, all nuclei. Scale bar = 100 μm. (B) EdU-positive cell quantification analysis. (C) The mRNA expressions of Coli, Alp, and Runx2 were detected using quantitative real-time polymerase chain reaction (qRT-PCR). Data are presented as means ± SDs from three separate experiments (n = 3). ns p > 0.05; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. SiNC: siRNA negative control; siNRF2: siRNA of NRF2.