Table 1.

Concentration of GTCs in plasma in interventional trials targeting men with PCa.

Author; Target Population	Dose of EGCG (mg)	Duration of Intervention	Plasma EGCG Concentration after Intervention
Nguyen et al. [84]; PCa patients prior to RP	800 (Poly E®)	3–6 weeks	146.6 pmol/mL
Kumar et al. [75]; Men with HGPIN	200 (BID) (Poly E®)	1 year	12.3 ng/mL (SD, 24.8) fed
Bettuzi et al. [67]; Men with HGPIN	200 (TID)	1 year	NA
Lane et al. [85]; Men with elevated PSA or negative prostate biopsy for PCa	GTC drink GTC capsules	6 months	24.9 nmoL/L 12.3 nmoL/L

BID, twice a day; EGCG, (−)-epigallocatechin-3-gallate; GTC, green tea catechins; HGPIN, high-grade prostatic intraepithelial neoplasia; PCa, prostate cancer; Poly E, Polyphenon E; PSA, prostate specific antigen; RP, radical prostatectomy; SD, standard deviation; TID, three times a day.