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. 2022 Aug 16;11(16):2539. doi: 10.3390/cells11162539

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CD38⁺Ly6C^hi monocytes represent the major monocytic source of ROS production and contribute to liver damage following E. histolytica infection. (A) Heat map of differentially regulated genes involved in ROS production and a graph showing fold changes in expression of Ncf1 mRNA in the liver during infection with E. histolytica or L. monocytogenes. (B) Gating scheme and histogram for ROS⁺ liver Ly6C^hi monocytes. Percentage and mean fluorescent intensity (MFI) of ROS⁺Ly6C^hi monocytes during (C) E. histolytica and (D) L. monocytogenes infection. (E) Percentage of ROS⁺CD38⁺ out of Ly6C^hiCD11b⁺ monocytes in both infection models. (F) Percentage of amebic liver abscess weight in relation to the left liver lobe in WT (C57BL/6) and Cd38^-/- mice. (G) Percentage of Ly6C^hi CD11b⁺ cells in the liver in naive, infected WT and Cd38^-/- mice. (* p < 0.05; ** p < 0.01; *** p < 0.001, **** p < 0.0001; Mann-Whitney U test).