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The genes and proteins of class I PI3K. The catalytic subunits p110α/p110β, the regulatory subunits p85α/p85β and the genes that encoded these subunits (PIK3CA, PIK3CB, PIK3R1 and PIK3R2) are shown. ABD, albumin binding domain; RBD, RAS-binding domain; C2, protein kinase C conserved region 2; Rho-GAP, Rho GTPase-activating protein; SH2, Src homology 2 domain; iSH2, inter-SH2; cSH2, C-terminal SH2.
