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. 2022 Aug 21;11(16):2604. doi: 10.3390/cells11162604
1-MT 1-methyl-D-tryptophan
3-HKYN 3-hydroxykynurenine
AhR aryl hydrocarbon receptor
AKI acute kidney injury
AP-1 activator protein 1
APCs antigen-presenting cells
ATP adenosine triphosphate
BTK Bruton’s tyrosine kinase
CCI cecal content injection
CLP cecal ligation, puncture
CpG-DNA cytosine-phosphate-guanine dinucleotides present in bacterial DNA
CVVH continuous veno-venous haemofiltration
CXCL1 C-X-C Motif Chemokine Ligand 1
CXCR2 C-X-C Motif Chemokine Receptor 2
DAMPs damage-associated molecular patterns
DCs dendritic cells
FLT3L FMS-related tyrosine kinase 3 ligand
fMLP N-formyl-methionyl-leucyl-phenylalanine
GCN2K general control nonderepressible 2 kinases
GFR glomerular filtration rate
GM-CSF granulocyte-macrophage colony-stimulating factor
HMGB1 high-mobility group box 1
i.v. intravenously
ICAM-1 intercellular adhesion molecule 1
ICU intensive care unit
IDO1 indoleamine 2,3-dioxygenase 1
IDO2 indoleamine 2,3-dioxygenase 2
IFN-ɣ interferon-gamma
IGFBP7 insulin-like growth factor-binding protein 7
IL-12 interleukin 12
IL-17A interleukin-17A
IL-6 interleukin 6
IL-8 interleukin 8
iNOS inducible nitric oxide synthase
IRAKM IL-1 receptor-associated kinase M
ITK IL-2 inducible T-cell kinase
KP kynurenine pathway
KYN kynurenine
KYNA kynurenic acid
LPS lipopolysaccharide
Mac-1 macrophage-1 antigen
MCP-1 monocyte chemoattractant protein-1
MIF migration inhibitory factor
MPO myeloperoxidase
mtDNA mitochondrial DNA
mTOR mammalian target of rapamycin
MyD88 Myeloid Differentiation Factor 88
NETs neutrophil extracellular traps
NFAT nuclear factor of activated T cells
NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells
NGAL neutrophil gelatinase-associated lipocalin
NK natural killer
NLRs nucleotide-binding oligomerization domain-like receptors
NOX-2 neutrophils possess enzymes-NADPH oxidase
PAMPs pathogen-associated molecular patterns
PDL1 programmed death-ligand 1
PPAR-α peroxisome proliferator-activated receptor α
QUIN quinolinic acid
ROS reactive oxygen species
RTECs renal tubular epithelial cells
SAKI sepsis-induced AKI
SIRS systemic inflammatory response syndrome
STAT3 signal transducer and activator of transcription 3
Syk spleen tyrosine kinase
TDO2 tryptophan 2,3-dioxygenase 2
TGF-β transforming growth factor β
Th17 T helper 17
Th2 T helper 2
TIMP-2 tissue inhibitor of metalloproteinase-2
TLR4 Toll-like receptor 4
TLRs Toll-like receptors
TNF-α tumor necrosis factor α
Tregs regulatory T cells
TRP trypthofan
VCAM-1 vascular cell adhesion molecule 1
WT Wild-type mice