1-MT |
1-methyl-D-tryptophan |
3-HKYN |
3-hydroxykynurenine |
AhR |
aryl hydrocarbon receptor |
AKI |
acute kidney injury |
AP-1 |
activator protein 1 |
APCs |
antigen-presenting cells |
ATP |
adenosine triphosphate |
BTK |
Bruton’s tyrosine kinase |
CCI |
cecal content injection |
CLP |
cecal ligation, puncture |
CpG-DNA |
cytosine-phosphate-guanine dinucleotides present in bacterial DNA |
CVVH |
continuous veno-venous haemofiltration |
CXCL1 |
C-X-C Motif Chemokine Ligand 1 |
CXCR2 |
C-X-C Motif Chemokine Receptor 2 |
DAMPs |
damage-associated molecular patterns |
DCs |
dendritic cells |
FLT3L |
FMS-related tyrosine kinase 3 ligand |
fMLP |
N-formyl-methionyl-leucyl-phenylalanine |
GCN2K |
general control nonderepressible 2 kinases |
GFR |
glomerular filtration rate |
GM-CSF |
granulocyte-macrophage colony-stimulating factor |
HMGB1 |
high-mobility group box 1 |
i.v. |
intravenously |
ICAM-1 |
intercellular adhesion molecule 1 |
ICU |
intensive care unit |
IDO1 |
indoleamine 2,3-dioxygenase 1 |
IDO2 |
indoleamine 2,3-dioxygenase 2 |
IFN-ɣ |
interferon-gamma |
IGFBP7 |
insulin-like growth factor-binding protein 7 |
IL-12 |
interleukin 12 |
IL-17A |
interleukin-17A |
IL-6 |
interleukin 6 |
IL-8 |
interleukin 8 |
iNOS |
inducible nitric oxide synthase |
IRAKM |
IL-1 receptor-associated kinase M |
ITK |
IL-2 inducible T-cell kinase |
KP |
kynurenine pathway |
KYN |
kynurenine |
KYNA |
kynurenic acid |
LPS |
lipopolysaccharide |
Mac-1 |
macrophage-1 antigen |
MCP-1 |
monocyte chemoattractant protein-1 |
MIF |
migration inhibitory factor |
MPO |
myeloperoxidase |
mtDNA |
mitochondrial DNA |
mTOR |
mammalian target of rapamycin |
MyD88 |
Myeloid Differentiation Factor 88 |
NETs |
neutrophil extracellular traps |
NFAT |
nuclear factor of activated T cells |
NF-κB |
nuclear factor kappa-light-chain-enhancer of activated B cells |
NGAL |
neutrophil gelatinase-associated lipocalin |
NK |
natural killer |
NLRs |
nucleotide-binding oligomerization domain-like receptors |
NOX-2 |
neutrophils possess enzymes-NADPH oxidase |
PAMPs |
pathogen-associated molecular patterns |
PDL1 |
programmed death-ligand 1 |
PPAR-α |
peroxisome proliferator-activated receptor α |
QUIN |
quinolinic acid |
ROS |
reactive oxygen species |
RTECs |
renal tubular epithelial cells |
SAKI |
sepsis-induced AKI |
SIRS |
systemic inflammatory response syndrome |
STAT3 |
signal transducer and activator of transcription 3 |
Syk |
spleen tyrosine kinase |
TDO2 |
tryptophan 2,3-dioxygenase 2 |
TGF-β |
transforming growth factor β |
Th17 |
T helper 17 |
Th2 |
T helper 2 |
TIMP-2 |
tissue inhibitor of metalloproteinase-2 |
TLR4 |
Toll-like receptor 4 |
TLRs |
Toll-like receptors |
TNF-α |
tumor necrosis factor α |
Tregs |
regulatory T cells |
TRP |
trypthofan |
VCAM-1 |
vascular cell adhesion molecule 1 |
WT |
Wild-type mice |