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. 2022 Aug 22;14(16):4042. doi: 10.3390/cancers14164042

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Side effect of NIR-PIT with Cet-IR700 in mEERL-hEGFR tumors: (A) edema was assessed by T2WI fat-sat MRI in the NIR-PIT-treated mice at 24 h; (B) the range of high signals was quantified using Image J (n = 3; one-way ANOVA followed by Tukey’s test; *, p < 0.05 and **, p < 0.01); (C) the appearance 24 h after light exposure, where the yellow circles indicate the edema-affected area; (D) the percentage of change from immediately before irradiation (n = 10; two-way ANOVA; N.S.: not significant).