Table 3.
Assessment of the usefulness of selected laboratory variables, including Extended Inflammation Parameters as well as calculated indicators—systemic inflammatory response markers and serous indirect markers of liver fibrosis in the diagnosis of LC.
| Variable | Sensitivity (%) | Specificity (%) | Cut-Off | AUC [95%CI] | p |
|---|---|---|---|---|---|
| RBC [106/µL] | 65 | 80 | >4.32 | 0.65 [0.46–0.82] | 0.1741 |
| MCV [fl] | 100 | 40 | >86.70 | 0.15 [0.37–0.74] | 0.6631 |
| PLT [103/µL] | 80 | 100 | >201.00 | 0.94 [0.77–0.99] | <0.0001 * |
| RDW-SD [fl] | 50 | 80 | ≤45.60 | 0.62 [0.43–0.79] | 0.2459 |
| MPV [fl] | 65 | 70 | ≤11.30 | 0.11 [0.44–0.81] | 0.2009 |
| WBC [103/µL] | 80 | 100 | >6.20 | 0.92 [0.76–0.99] | <0.0001 * |
| NEUT [103/µL] | 50 | 100 | <1.84 | 0.78 [0.59–0.91] | 0.0069 * |
| LYMPH [103/µL] | 100 | 80 | >0.91 | 0.90 [0.73–0.98] | <0.0001 * |
| MONO [103/µL] | 55 | 100 | >0.58 | 0.79 [0.60–0.92] | 0.0006 * |
| IG [103/µL] | 95 | 50 | >0.01 | 0.77 [0.58–0.90] | 0.0072 * |
| NEUT-RI [FI] | 90 | 50 | ≤49.50 | 0.58 [0.39–0.76] | 0.5368 |
| NEUT-GI [SI] | 65 | 100 | >152.80 | 0.89 [0.73–0.98] | <0.0001 * |
| AS-LYMP [103/µL] | 0 | 100 | >0.00 | 0.50 [0.31–0.69] | 1.0000 |
| RE-LYMP [103/µL] | 85 | 60 | ≤0.09 | 0.68 [0.48–0.84] | 0.1550 |
| CRP [mg/L] | 60 | 66.67 | ≤3.00 | 0.55 [0.36–0.74] | 0.6623 |
| MPR | 75 | 100 | ≤0.05 | 0.93 [0.78–0.99] | <0.0001 * |
| PLR | 75 | 90 | >7.28 | 0.86 [0.68–0.96] | <0.0001 * |
| RPR | 85 | 90 | ≤0.08 | 0.91 [0.75–0.98] | <0.0001 * |
| RLR | 100 | 30 | ≤1.37 | 0.57 [0.38–0.75] | 0.5921 |
| NLR | 35 | 50 | >3.29 | 0.50 [0.31–0.69] | 1.0000 |
| GPR | 25 | 90 | ≤0.40 | 0.51 [0.33–0.70] | 0.8993 |
| AAR | 50 | 90 | ≤0.84 | 0.73 [0.54–0.88] | 0.0172 * |
| APRI | 55 | 90 | ≤0.93 | 0.72 [0.53–0.87] | 0.0209 * |
| FIB-4 | 60 | 100 | ≤1.47 | 0.83 [0.65–0.94] | <0.0001 * |
RBC—Red Blood Cells. MCV—Mean Cell Volume. PLT—Platelets. RDW-SD—Red Blood Cell Distribution Width. Standard Deviation. MPV—Mean Platelet Volume. WBC–White Blood Cells. NEUT—Neutrophils. LYMPH—Lymphocytes. MONO—Monocytes, IG—Immature Granulocytes. NEUT-RI—Neutrophil Reactive Intensity. NEUT-GI—Neutrophil Granularity Intensity. AS-LYMP—Antibody-Secreting Reactive Lymphocytes. RE-LYMP—Reactive Lymphocytes. CRP—C-Reactive Protein. MPR—Mean Platelet Volume-to-Platelet Ratio. PLR—Platelet-to-Lymphocyte Ratio. RPR—Red Blood Cell Distribution Width-to-Platelet Ratio. RLR—Red Blood Cell Distribution Width-to-Lymphocyte Ratio. NLR—Neutrophil-to-Lymphocyte Ratio. GPR—Gamma-Glutamyl-Transpeptidase-to-Platelet Ratio. AAR—Aspartate Aminotransferase–to-Alanine Aminotransferase Ratio. APRI—Aspartate Aminotransferase-to-Platelet Ratio Index. FIB-4—Fibrosis-4. AUC—Area under curve. * Statistically significant result.