Figure 1.
Overview of the pathological changes of cardiomyocytes in cardiotoxicity induced by cancer therapies, the resulting morphological and functional changes of the heart, and CMR assessments that have been performed in previous studies. Different CMR parameters may increase (red arrows) or decrease (blue arrows) or be positive (red plus) in cardiotoxicity. LV = left ventricular; LVEF = left ventricular ejection fraction; LVESV = LV end-systolic volume; LVEDV = LV end-diastolic volume; GLS = global longitudinal strain; RVEF = right ventricular ejection fraction; T1WI = T1-weighted imaging; T2WI = T2-weighted imaging; LGE = late gadolinium enhancement; ECV = extracellular volume fraction.