Table 2.

Advantages and limitations of different imaging techniques in the diagnosis of cardiotoxicity.

Imaging Techniques	Monitoring Index or Characteristic	Advantages	Limitations
MUGA	LVEF	Reproducibility	Radiation exposure Limited morphological and functional information of other cardiac chambers and extra-cardiac structures
Echocardiography	LVEF RVEF Strain (GLS, GCS, GRS) LV mass	Wide availability High portability No radiation Morphological and functional information Valvular function Low cost	Suboptimal acoustic window High operator dependency High variability GLS: inter-vendor variability and technical requirements
CMR	LVEF RVEF Strain (GLS, GCS, GRS) LV mass Edema Inflammation Fibrosis	Reproducibility Accuracy No radiation Morphological and functional information Valvular function Tissue characterization	Limited availability High cost Technical requirements Patient adaptation (contraindications for CMR: difficulty in holding breath or lying flat)

MUGA = multi-gated radionuclide angiography; CMR = cardiovascular magnetic resonance; LVEF = left ventricular ejection fraction; RVEF = right ventricular ejection fraction; GLS = global longitudinal strain; GCS = global circumferential strain; GRS = global radial strain.