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. 2022 Aug 19;11(16):2588. doi: 10.3390/cells11162588

Figure 2.

Figure 2

Effect of ABT-737 on senescent cells. (A) Representative images of proliferating (PRO) and senescent (CSEN) LN229 and A172 cells without (control) and with 2.5 µM ABT-737 treatment. (B) Treatment of senescent LN229 and A172 cells with increasing concentrations of ABT-737 leads to a significant decrease in cell viability, as shown by MTT assay. (C) Decrease in senescence and increase in apoptosis shown by flow cytometry when senescent LN229 and A172 cells were treated with a non-toxic concentration (2.5 µM) of Abt-737. Data in (B,C) represent the mean of >3 independent experiments ± SEM. * p < 0.05, ** p < 0.01.