Table 3.
Changes in ventilatory support requirements following treatment with Nusinersen.
| Author/Year | Reduction in NIV/IMV Support | Discontinued NIV | Unchanged NIV/IMV Support | Criteria for Ventilator Support Changes |
|---|---|---|---|---|
| Ali et al./2019 [36] | 0 | 0 | 5/6 | n/m |
| Ogawa et al./2019 [37] | 0 | 0 | 1/1 | Parameters on the ventilator |
| Pane et al./2019 [38] | 2/35 | 0 | 11/35 | n/m |
| Kim et al./2020 [39] | 2/4 | 0 | 2/4 | n/m |
| Kouri et al./2020 [40] | 0 | 1/1 | 0 | Polysomnography |
| Sansone et al./2020 [32] | 3/88 | 0 | 75/88 | Oximetry and gas exchange evaluation |
| Tiberi et al./2020 [41] | 0 | 0 | 0/1 | n/m |
| De HolandaMendonca et al./2021 [42] | 6/21 | 0 | 14/21 | n/m |
| Lavie et al./2021 [43] | 0 | 0 | 13/15 | Polysomnography Chest wall deformities |
| Tanaka et al./2021 [44] | 0 | 0 | 1/1 | n/m |
|
Total
Nusinersen |
13/172 (7.5%) | 1/172 (0.6%) | 122/172 (70.9%) | n/m |
Abbreviations: IMV: invasive mechanical ventilation via tracheostomy; NIV: noninvasive ventilation; N/M: not mentioned; SMN: survival motor neuron.