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. 2022 Aug 20;14(16):4027. doi: 10.3390/cancers14164027

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Time- and concentration-dependent effects of dasatinib, trametinib, and their combination on the growth and survival of MDA-MB-231 cells. (a) Growth curves of MDA-MB-231 control cells (1) under the treatment of 1 μM trametinib (2), dasatinib (3), or the trametinib + dasatinib combination (4). (b) Dose-dependent effects of 1 h and 48 h treatments with trametinib on MDA-MB-231 cells. (c) Dose-dependent effects of 1 h and 48 h treatments with dasatinib on MDA-MB-231 cells. (d) Dose-dependent effects of 1 h and 48 h treatments with trametinib + dasatinib on MDA-MB-231 cells. (e) Effects of 100 nM trametinib (T), dasatinib (D), and their combination (T + D) on the cleavage of caspases 3 and 7 and PARP, determined by Western blots. Uncropped Western Blots and densitometry can be found at supplementary.