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. 2022 Aug 11;14:923673. doi: 10.3389/fnagi.2022.923673

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Copyright © 2022 Liu, Zhu, Sun, Zhang, Feng, Gjerswold-Selleck, Sikka, Zhu, Liu, Nuriel, Wei, Wu, Vaughan, Laine, Provenzano, Small and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DeepContrast maps age-related changes in brain regions vulnerable and resistant to aging. (A) A three-dimensional rendering of the inferior frontal gyrus (IFG), dentate gyrus (DG) and entorhinal cortex (EC) overlaid on a group-wise T1-weighted MRI template. (B) The age-related regressions of CBV maps over these regions demonstrate the aging-vulnerability of IFG and DG and the aging-resistance of EC. (C) The age-related regressions of synthesized CBV maps over the same regions demonstrated the same vulnerability or resistance to aging. (D) The scatter plots of the ROI-mean CBV vs. synthesized CBV values of the 177 participants further show the consistency of the two measures.