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. 2022 Aug 11;14:923673. doi: 10.3389/fnagi.2022.923673

Figure 6.

Figure 6

DeepContrast maps age-related changes over the entire cortex. (A) Three-dimensional volume rendering of the age-related t-score maps over the 72 FreeSurfer cortical region-of-interests (ROIs) reveals that the age-related changes in the synthesized CBV maps is similar to those in the ground truth CBV maps, despite that the non-contrast T1W scans which serves as the input to the DeepContrast model does not share either the same or the opposite trends. (B) A scatter plot of the age-related t-score over the 72 ROIs demonstrates that the age-related changes in synthesized CBV are consistent to those in CBV (P.R = 0.816, S.R = 0.786) while the T1W counterparts do not (P.R = –0.131, S.R = –0.122). (C) An analysis of the concordance to CBV t-scores by treating it as a 1,000-class classification problem reveals that age-related changes in synthesized CBV have significant predictive power on those in CBV (sensitivity = 0.76, specificity = 0.89, AUC = 0.91) while the T1W counterparts do not (sensitivity = 1.00, specificity = 0.04, AUC = 0.43).