Architectural criteria (mandatory, major)
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Lentiginous or contiguous melanocytic hyperplasia |
Poor circumscription of the intraepidermal melanocytic component of the lesion |
Focal melanocytic atypia |
Increased number of melanocytes, solitary and in nests, within and above the epidermal basal cell layer and within adnexal epithelia (pagetoid spreading) |
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Marked variation in size and shape of the melanocytic nests |
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Absence of maturation of melanocytes with descent into the dermis |
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Melanocytes in mitosis |
Architectural criteria (minor, at least 2)
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“Shoulder phenomenon” |
Melanocytes with nuclear atypia |
Fusion of epithelial cones |
Necrosis or degeneration of melanocytes |
Subepidermal concentric lamellar fibrosis |
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