Fig. 1.

Interaction of WT, M32-4, M70-2, and M32-4/70-2 with RPA and DNA. (A) Domain map of XPA. Interaction sites with other protein and mutants introduced in this study are highlighted. (B) Isothermal titration calorimetry thermograms of XPA mutants and full-length RPA showing the raw heat release (Upper) and integrated heat release (Lower). XPA proteins used are indicated. For the titrations in i–iv, the first injection of 1 µL was removed for analysis. The thermograms in B are representative of one of three or more replicates.