Figure 2.

Application of extracellular stress leads to increased intracellular calcium concentrations. Matthews et al. applied high levels of stress to cells (A) and found that when imaged via Fura-2AM ratio imaging, it led to a transient increase in calcium concentrations, as shown in pseudocolor images ranging from blue to yellow (B) that is quantified (C) as a function of time for control and gadolinium chloride-treated cells. (Figure reprinted/adapted with permission from Ref. [61]. Copyright 2006, National Academy of Sciences.