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. 2022 Aug 10;8(8):496. doi: 10.3390/gels8080496

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Extracellular matrix (ECM) of the brain. The ECM of the brain has a unique composition, including hyaluronic acid, collagen IV, and other ECM components along with glial cells, neurons, and astrocytes. The blood-brain barrier (BBB) is a neurovascular unit composed of vascular endothelial cells with surface charge modifications, tight junction proteins, pericytes, astrocytes, and other components. The BBB is selectively permeable and can block solutes in the systemic blood from entering the environment of the central nervous system (Created with BioRender.com, accessed on 14 July 2022).