Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Three-dimensional genome organization and loop extrusion model. (A) The topological structures of the 3D genome are organized at four levels, comprising chromosome territories, A/B compartments, TAD, and chromatin loops. (B) DNA loop extrusion model. Cohesin binds to DNA and begins to extrude symmetrically until it encounters a convergent-oriented CTCF to form a chromatin loop.
