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. 2022 Aug 15;119(34):e2207592119. doi: 10.1073/pnas.2207592119

Fig. 1.

Fig. 1.

VWF is increased during VOE in SCD mice. (A) Hemoglobin levels and platelet counts of A/A and S/S mice at baseline and 3 h after TNF challenge are shown. Each dot represents one mouse. Data represent mean ± SD. ****P < 0.0001; ns, nonsignificant, repeated measures 2-way ANOVA. (B) Plasma VWF levels in A/A and S/S mice at baseline and 3 h after TNF challenge are shown. Each dot represents one mouse. Data represent mean ± SD. **P < 0.01; ns, nonsignificant, repeated measures 2-way ANOVA. (C) Representative immunofluorescence images of cryosections of liver, kidney, and lung collected from A/A and S/S mice at 3 h after VOE induction. Scale bar, 50 μm. Quantification of the percentage of vaso-occlusion area per field of view (FOV) using ImageJ is shown on the right. n = 4 mice per genotype. Data represent mean ± SD. ***P < 0.001, two-tailed, unpaired Student’s t test.