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. 2022 Aug 9:eabq7647. doi: 10.1126/sciimmunol.abq7647

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Fig. 2. — Antibody responses at weeks 0, 4, and 6 following vaccination with Ad26.COV2.S and following challenge. A, Neutralizing antibody (NAb) titers by a luciferase-based pseudovirus neutralization assay. B, Receptor binding domain (RBD)-specific binding antibody titers by ELISA. C, Pooled peptide Spike-specific IFN-γ CD8⁺ and CD4⁺ T cell responses by intracellular cytokine staining assays at week 2 following vaccination with Ad26.COV2.S. Responses were measured against the SARS-CoV-2 WA1/2020 (black), B.1.617.2 (Delta; blue), and B.1.1.529 (Omicron; green) variants. Dotted lines represent limits of quantitation. Medians (red bars) are shown.