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. 2022 Aug 4:eabp9962. doi: 10.1126/sciimmunol.abp9962

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Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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Fig. 6. — (A) Illustration of mouse antibody humanization strategy. (B) The kinetics of humanized SW186 (H2L3) binding to the spike protein using BLI. The K_D value is mean ± SD, n=3. (C) This heatmap summarizes the mean K_D values of humanized SW186 antibodies binding to the spike protein of SARS-CoV-2 (Wuhan-hu-1 strain) as measured by BLI. The binding kinetic parameters are summarized in table S4. (D) Neutralization activities (IC₅₀ at ng/mL) of humanized antibodies against SARS-CoV-2 Delta pseudovirus. Antibodies were serially diluted 1:3 from 30 μg/mL for 7 dilutions, with each dilution in duplicate.