Table 2.
High-resolution respirometry findings in animal obesity studies.
| Animal Model | Tissue Type | Main Effects | Normalization | Ref. |
|---|---|---|---|---|
| Zucker rats | Skeletal muscle (Soleus muscle) |
Decreased OXPHOS capacity in adult No change in OXPHOS capacity in young |
Citrate synthase |
[32] |
| Wistar rats | Skeletal muscle (left diaphragm) |
No change in ROUTINE respiration No change in LEAK respiration No change in ROX Increased OXPHOS capacity Increased ET capacity |
Tissue mass | [33] |
| SPF male B6 and D2 mice | Liver tissue | Decreased OXPHOS capacity Decreased ET capacity Decreased RCR |
Tissue mass | [34] |
| C57BL/6J male mice | Heart muscle (Langendorff-perfused hearts) |
Decreased ROUTINE respiration Decreased NADH-linked OXPHOS capacity No change in RCR |
Tissue protein | [35] |
| Zucker rats | Heart muscle (Langendorff-perfused hearts) |
Decreased OXPHOS capacity Decreased ET capacity No change in LEAK respiration No change in RCR |
Tissue mass | [36] |