Table 1.
Allele frequency, genotype distribution and Hardy–Weinberg equilibrium of IRS-1 Gly972Arg polymorphism in PCOS as compared with control women.
| Allele/ | Cases | Controls | Total | OR | χ2 |
|---|---|---|---|---|---|
| Genotype | (n = 249) | (n = 100) | (n = 349) | (95% CI) | (p) |
| G | 395 (79.3%) |
154 (77.0%) | 498 | 0.87 (0.59–1.29) |
0.45 (0.499) |
| A | 103 (20.7%) |
46 (23.0%) |
200 | ||
| GG | 154 (61.85%) |
56 (56.00%) |
210 (63.90%) |
- | 3.73 (0.15) |
| GA | 87 (34.94%) |
42 (42.00%) |
129 (27.22%) |
||
| GG | 8 (3.21%) |
2 (2.00%) |
10 (8.88%) |
||
| HWE | 1.05 (0.306) |
3.45 (0.063) |
3.54 (0.06) |
- | - |
PCOS: polycystic ovary syndrome, G and A: alleles for Gly972Arg polymorphism, CI: confidence interval, χ2: Pearson’s chi-squared test with Yates correction. Data of alleles are presented as number (%) of PCOS and controls. GG, GA and AA: genotypes of IRS-1 (G/A) polymorphism in PCOS and controls, HWE: χ2 Hardy–Weinberg equilibrium. (p): p value data of alleles are presented as number (%) of PCOS and controls.