Table 4.
Comparison of anthropometric, hormonal, metabolic and biochemical parameters of PCOS cases and healthy controls in IRS-1 Gly972Arg polymorphism in recessive genotype model.
| Parameter | PCOS | p Value | Controls | p Value | ||
|---|---|---|---|---|---|---|
| GG (n = 154) | GA + AA (n = 95) | GG (n = 56) | GA + AA (n = 44) | |||
| Age (years) | 22.21 ± 3.74 | 22.82 ± 4.72 | 0.25 | 22.11 ± 3.21 | 21.73 ± 3.00 | 0.58 |
| Weight (kg) | 59.12 ± 10.68 | 60.98 ± 12.91 | 0.24 | 50.77 ± 6.43 | 53.43 ± 6.86 | 0.04 * |
| Height (m) | 1.58 ± 0.05 | 1.56 ± 0.05 | 0.05 | 1.56 ± 0.06 | 1.58 ± 0.05 | 0.07 |
| BMI (kg/m2) | 23.87 ± 4.41 | 24.96 ± 4.76 | 0.06 | 20.89 ± 2.32 | 21.52 ± 2.64 | 0.20 |
| Waist (cm) | 82.63 ± 10.88 | 83.86 ± 10.83 | 0.38 | 76.80 ± 7.41 | 77.27 ± 6.77 | 0.74 |
| Hip (cm) | 92.44 ± 8.25 | 95.15 ± 8.19 | 0.012 * | 90.52 ± 6.26 | 92.30 ± 6.36 | 0.16 |
| WHR | 0.89 ± 0.09 | 0.88 ± 0.07 | 0.35 | 0.85 ± 0.06 | 0.84 ± 0.05 | 0.37 |
| SBP (mmHg) | 120.50 ± 7.36 | 120.67 ± 7.58 | 0.86 | 118.93 ± 5.54 | 119.00 ± 5.29 | 0.94 |
| DBP (mmHg) | 80.50 ± 5.46 | 81.07 ± 6.40 | 0.45 | 79.21 ± 5.27 | 79.45 ± 5.23 | 0.82 |
| Menarche (years) | 13.19 ± 1.14 | 13.05 ± 1.12 | 0.34 | 13.30 ± 1.04 | 13.25 ± 1.12 | 0.81 |
| LH (IU/L) | 12.28 ± 10.92 | 9.95 ± 6.62 | 0.06 | 6.51 ± 2.52 | 6.83 ± 2.14 | 0.50 |
| FSH (IU/L) | 5.94 ± 1.66 | 6.32 ± 2.15 | 0.11 | 6.87 ± 1.95 | 6.93 ± 2.03 | 0.88 |
| TT (ng/dL) | 61.22 ± 20.89 | 60.86 ± 26.20 | 0.90 | 33.90 ± 16.89 | 34.46 ± 13.97 | 0.85 |
| PRL (ng/mL) | 13.56 ± 5.84 | 12.86 ± 5.22 | 0.34 | 10.71 ± 5.28 | 10.06 ± 4.49 | 0.51 |
| SHBG (nmol/L) | 51.30 ± 23.33 | 48.10 ± 18.59 | 0.20 | 62.86 ± 23.34 | 67.51 ± 27.91 | 0.36 |
| Andro (ng/mL) | 3.32 ± 0.78 | 3.14 ± 1.03 | 0.11 | 2.30 ± 0.74 | 2.20 ± 0.62 | 0.47 |
| Insulin F (μIU/mL) | 12.86 ± 6.66 | 14.61 ± 7.22 | 0.05 | 7.45 ± 6.08 | 8.07 ± 4.41 | 0.57 |
| Glu F (mg/dL) | 85.37 ± 8.04 | 86.23 ± 9.43 | 0.44 | 84.31 ± 9.39 | 84.84 ± 8.26 | 0.76 |
| Glu 2 h (mg/dL) | 117.69 ± 19.11 | 112.82 ± 17.21 | 0.04 * | 109.25 ± 15.87 | 107.66 ± 12.09 | 0.58 |
| Chol (mg/dL) | 157.56 ± 36.63 | 150.14 ± 30.78 | 0.10 | 132.57 ± 18.98 | 138.34 ± 19.44 | 0.13 |
| TG (mg/dL) | 121.13 ± 38.75 | 119.73 ± 29.88 | 0.76 | 101.20 ± 13.18 | 104.68 ± 16.54 | 0.24 |
| QUICKI | 0.331 ± 0.02 | 0.326 ± 0.02 | 0.05 | 0.38 ± 0.04 | 0.37 ± 0.05 | 0.26 |
| FAI | 5.89 ± 6.26 | 5.56 ± 4.40 | 0.65 | 2.20 ± 1.50 | 2.23 ± 1.86 | 0.92 |
| LAP | 34.38 ± 21.38 | 36.42 ± 22.55 | 0.49 | 21.64 ± 9.39 | 22.91 ± 8.74 | 0.49 |
| Urea | 23.45 ± 6.20 | 21.61 ± 5.43 | 0.01 * | 21.38 ± 3.58 | 21.23 ± 3.37 | 0.83 |
| Creatinine (mg/dL) | 1.01 ± 0.44 | 1.06 ± 0.40 | 0.36 | 0.78 ± 0.12 | 0.83 ± 0.15 | 0.06 |
| UA (mg/dL) | 4.27 ± 1.06 | 4.28 ± 1.13 | 0.94 | 3.77 ± 0.66 | 3.94 ± 0.86 | 0.26 |
| AST (U/L) | 32.81 ± 13.78 | 29.10 ± 9.60 | 0.02 * | 18.23 ± 7.83 | 18.40 ± 7.95 | 0.91 |
| ALT (U/L) | 29.08 ± 15.23 | 25.83 ± 10.95 | 0.07 | 23.01 ± 6.42 | 24.03 ± 7.25 | 0.45 |
Data presented as mean ± SD. * p value < 0.05 was considered significant as calculated by independent Student’s t-test. PCOS: polycystic ovary syndrome, BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, FG score: Ferriman–Gallweyscore, LH: luteinizing hormone, FSH: follicle-stimulating hormone, TT: total testosterone, PRL: prolactin, TSH: thyroid-stimulating hormone, SHBG: sex hormone-binding globulin, Andro: androstenrdione, DHEAS: dihydroepiandrostenedione sulphate, Glu F: glucose fasting, CHOL: cholesterol, TG: triglycerides, QUICKI: quantitative insulin sensitivity check index, FAI: free androgen index, UA: uric acid, AST: aspartate aminotransferase, ALT: alanine aminotransferase.