Table 5.
Genotypic–phenotypic association of clinical symptoms of hyperandrogenism, oligo-anovulation and insulin resistance in IRS-1 Gly972Arg genotypes in PCOS women.
| Clinical Feature | GG (n = 154) |
GA (n = 87) |
AA (n = 8) |
GA + AA (n = 95) | (χ2) p a | (χ2) p b |
|---|---|---|---|---|---|---|
| Acne | 100 (64.93%) | 38 (43.67%) | 4 (50.00%) | 42 (44.21%) | (10.41) 0.005 | (10.29) 0.00 |
| Alopecia | 70 (45.45%) | 24 (27.58%) | 3 (37.5%) | 27 (28.72%) | (7.47) 0.02 | (7.17) 0.00 |
| Acanthosis | 46 (29.87%) | 34 (39.08%) | 3 (37.5%) | 37 (39.36%) | (2.19) 0.33 | (2.18) 0.13 |
| Hirsutism | 131 (85.06%) | 56 (64.36%) | 3 (37.5%) | 58 (61.70%) | (20.06) <0.001 | (18.52) 0.00 |
| Oligomenorrhea | 148 (96.1%) | 57 (65.51%) | 8 (100%) | 65 (69.15%) | 43.45) <0.001 | (36.4) 0.00 |
| Obesity | 61 (39.61%) | 45 (51.72%) | 4 (50.00%) | 49 (52.13%) | (3.42) 0.18 | (3.41) 0.06 |
| Insulin resistance | 73 (47.40%) | 46 (52.87%) | 4 (50.00%) | 50 (53.19%) | (0.67) 0.71 | (0.64) 0.42 |
Data presented as number (percent). Clinical features defined as: hirsutism FGS ≥ 8, obesity BMI ≥ 25 kg/m2, insulin resistance HOMA ≥ 2.71, p value calculated by chi-squared test. (χ2) p a p value of GG vs. GA vs. AA calculated by chi-squared test, (χ2) p b p value of GG vs. GA + AA calculated by chi-squared test. Oligomenorrhea defined as <9 menstrual cycles per year.