Table 2.
Percentage change in gene expression level in fibroblasts under the influence of exosomes of various origins.
| Gene/Cell Line | SKOV-3 C | SKOV-3 MA | SKOV-3 CIS | SKOV-3 MA/CIS | TOV-21G C | TOV-21G MA | TOV-21G CIS | TOV-21G MA/CIS |
|---|---|---|---|---|---|---|---|---|
| APC | 99.39% | 87.82% | 93.71% | 86.27% | 99.37% | 78.79% | 93.60% | 93.81% |
| CD44 | 829.24% | 30.10%↑ | 504.20% | 32.91%↑ | 576.30% | 283.19% | 372.95% | 354.89% |
| CDH1 | 47.03% | 67.05% | 26.00% | 49.53% | 37.42% | 53.42% | 98.99% | 96.13% |
| FXYD5 | 109.88% | 49.87%↑ | 47.59%↑ | 17.36%↓ | 361.58% | 61.98%↑ | 133.61% | 234.56% |
| VEGFA | 53.80%↑ | 27.68%↓ | 15.72%↑ | 1.15%↓ | 114.63% | 130.15% | 88.39% | 86.79% |
| RPSA | 30.19% | 83.91% | 60.77% | 62.23% | 1.98%↑ | 67.04% | 53.47% | 74.87% |
| MMP10 | 518.37% | 229.48% | 137.07% | 330.45% | 1051.65% | 81.09%↑ | 678.33% | 313.18% |
| MMP2 | 179.59% | 241.91% | 254.42% | 47.46%↑ | 1078.63% | 48.61%↑ | 107.38% | 82.02%↑ |
| TIMP2 | 246.36% | 128.27% | 196.11% | 137.30% | 382.59% | 51.47%↑ | 40.25%↑ | 43.06%↑ |
| TIMP3 | 19.27%↓ | 29.60%↓ | 15.35%↓ | 29.09%↓ | 543.83% | 119.98% | 452.10% | 327.60% |
| BRMS1 | 96.37% | 78.58% | 84.43% | 94.40% | 91.21% | 72.59% | 74.60% | 83.28% |
| HRAS | 1590.08% | 14.47%↑ | 151.61% | 52.19%↑ | 1176.03% | 142.21% | 8.41%↑ | 183.73% |
| SET | 58.26% | 27.59% | 51.94% | 28.27% | 188.20% | 143.78% | 117.53% | 142.40% |
| TP53 | 71.28% | 16.22% | 27.85% | 46.03% | 33.96% | 46.88% | 59.00% | 4.31%↓ |
| MDM2 | 141.38% | 41.05%↑ | 46.42%↑ | 17.24%↑ | 61.11%↑ | 36.23%↑ | 38.84%↑ | 60.42%↑ |
| IL18 | 235.74% | 72.06% | 108.94% | 33.00%↑ | 222.51% | 149.71% | 149.64% | 55.51%↑ |
| CCL7 | 252.36% | 68.80%↑ | 226.99% | 34.13%↑ | 727.94% | 216.20% | 345.70% | 534.28% |
| CXCL12 | 458.65% | 28.53%↑ | 122.94% | 219.99% | 240.47% | 28.78%↑ | 168.37% | 65.49% |
| CXCR4 | 165.75% | 31.19%↑ | 78.77% | 23.93%↑ | 92.08% | 30.30%↑ | 22.70%↑ | 68.72% |
NHDF cells not treated with exosomes were taken at the level of 100%. The red color shows the genes that showed a statistically significant increase in expression (p < 0.05). The red arrow shows the genes that showed a statistically insignificant increase in expression. The green color shows the genes that showed a statistically significant decrease in expression (p < 0.05). The green arrow shows the genes that showed a statistically insignificant decrease in expression.