Table 1.
BQ-123-CHI and R-954-HA nanogels physicochemical characteristics. Mean and standard deviations of hydrodynamic diameter (DH (nm)), polydispersity index (PdI), and zeta potential (ZP) were measured by dynamic light scattering and electrophoretic light scattering, respectively. The amount of free, non-encapsulated peptide was quantified by spectrofluorometry and used to determine the drug loading (DL). n = 2 batches for BQ-123-CHI, and n = 3 batches for R-954-HA.
| Size (DH, nm) | PdI | ZP (mV) | DL (%) | |
|---|---|---|---|---|
| BQ-123-CHI | 733 ± 169 | 0.60 ± 0.3 | 47 ± 5 | 1.35–2.60 |
| R-954-HA | 429 ± 52 | 0.29 ± 0.0 | 51 ± 8 | 0.30–0.63 |