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METH disrupts mitochondrial membranes. (A) Representative TEM micrographs showing that METH dose-dependently increases the ruptures of inner and outer membranes (arrowhead) of mitochondria (M). (B) The graph reports mitochondria with ruptured membranes. Values are given as the mean ± S.E.M from N = 50 cells per group. * p ≤ 0.05 compared with controls; # p ≤ 0.05 compared with controls and METH 10 μM and 100 μM. Scale bars = 160 nm.
