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Schematic overview of the modulation of Th cell lineage development by EGCG. When activated by antigen-presenting cells, naïve CD4+ T cells can differentiate into various effector cell subtypes, depending on the local cytokine milieu. In the presence of an inflammatory cytokine milieu, dominated by the presence of IL-1β, IL-6, IL-23 and TGF-β, Th17 lineage determination is favored with the concomitant production of the Th17 cell signature cytokine IL-17A.
