WD	Western diet
MD	Mediterranean diet
T2DM	Type 2 diabetes mellitus
T3DM	Type 3 diabetes mellitus
CDC	Centers for Disease Control and Prevention
BMI	Body mass index
AD	Alzheimer’s disease
FTD	Frontotemporal dementia
LBD	Lewy body dementia
VD	Vascular dementia
WAT	White adipose tissue
TNF-α	Tumor necrosis factor alpha
IL-6	Interleukin 6
SVF	Stromal vascular fraction
SREBP	Sterol regulatory element-binding protein
FTO	Fat mass and obesity-related
LEPR	Leptin receptor
MCR4	Melanocontin 4 receptor
SNP	Single nucleotide polymorphism
PCOS	Polycystic ovary syndrome
INSIG2	Insulin-induced gene 2
PCKS1	Proprotein convertase subtilisin/kexin type 1
PPARG	Peroxisome proliferator-activated receptor gamma
BAT	Brown adipose tissue
UPC1	Uncoupling protein 1
miRNA	Micro-RNA
HFD	High-fat diet
IGF	Insulin growth factor
RXRα	Retinoid X receptor alpha gene
CNS	Central nervous system
HDAC	Histone deacetylase
IGF2	Insulin-like growth factor 2
TLR4	Toll-like receptor 4
NEMO	NF-κB essential modulator
GSK-3β	Glycogen synthase kinase 3β
HAN	Hypothalamic arcuate nucleus
KCNQ1	Potassium channel voltage gated KQT-like subfamily member 1 (KCNQ1)
KLF14	Kruppel-like factor 14
MSH	Melanocyte-stimulating hormone
MCRs	Melanocortin receptors
POMC	Proopio melanocortin
DNA	Deoxyribonucleic acid
ROS	Reactive oxygen species
IR	Insulin resistance
SNS	Sympathetic nervous system
GHTT	Glucopyranosyloxy1-hydroxytrideca
CRP	C-reactive protein
PDI	Protein disulfide isomerase
ER	Endoplasmic reticulum
MDD	Major depressive disorder
CFS	Cerebrospinal fluid
FDA	Federal Drug Administration
ARC	Arcuate nucleus
MRI	Magnetic resonance imaging
BBB	Blood–brain barrier
PUFA	Polyunsaturated fatty acids
AMPK	AMP activated protein kinase
US	United States