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. 2022 Aug 17;23(16):9279. doi: 10.3390/ijms23169279

Figure 3.

Figure 3

The effect of HVE and HT treatment (24 h) on the release of IL-6 using differentiated HaCaT cells challenged by TNF-α (10 ng/mL)/IFN-γ (10 ng/mL) (a,b) or TNF-α (10 ng/mL)/IL-4 (100 ng/mL) (c,d), measured by the ELISA assay. HT was not effective until the highest concentration tested (10 μM corresponding to 4.93 μg/mL). The data are expressed in percentages, relative to the stimulated control, which is arbitrarily assigned a value of 100%. ** p < 0.01, *** p < 0.001 versus stimulus. HVE, Hamamelis virginiana bark extract; reference inhibitors: E, epigallocatechin gallate (20 μM); A, apigenin (20 μM); S6I, STAT-6 inhibitor (50 nM).