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. 2022 Aug 17;23(16):9279. doi: 10.3390/ijms23169279

Figure 4.

Figure 4

The inhibitory effect of HVE treatment (24 h) on the NF-κB-driven transcription in HaCaT cells challenged by TNF-α (10 ng/mL)/IFN-γ (10 ng/mL) (a) or TNF-α (10 ng/mL)/IL-4 (100 ng/mL) (b), measured by plasmid transfection. The involvement of HT (10 μM corresponding to 4.93 μg/mL) in the inhibitory effect against TNF-α/IL-4 challenge was excluded (c). The data are expressed in percentages, relative to the stimulated control, which is arbitrarily assigned a value of 100%. * p < 0.05, ** p < 0.01, *** p < 0.001 versus stimulus. HVE, Hamamelis virginiana bark extract; reference inhibitors: A, apigenin (20 μM); S6I, STAT-6 inhibitor (50 nM).