Table 3.
List of nanofibrous scaffolds used in BTE for the release of drugs and GFs.
| GF(s) | Carrier Material | Drugs | Application | Ref. |
|---|---|---|---|---|
| Collagen PEG, PLGA, Polylactide/polyglicolide |
Gentamicin Tobramycin and cefazolin gentamicin |
Osteomyelitis | [224] | |
| BMP-7 | Poly(d,l-lactic acid) (PDLLA) | Pamidronate | Bone formation | [225] |
| - | HA-coated starch scaffold | Sodium clodronate | Bone tissue regeneration | [226] |
| BMP-2 | Alginate/Collagen | - | Regeneration of femoral segmental defects | [227] |
| - | PCL loaded with HA and BP PLGA/HA |
Clodronate Alendronate |
Bone formation | [228] |
| PDGF-A | PLGA | - | Enhanced bone regeneration | [229] |
| BMP-2 | Coating of silica xerogel–chitosan on porous HA scaffold | - | Improved bone regeneration | [230] |
| rhBMP2 | SF/PLGA | DXM (dexamethasone) | Promising potential for boosting of bone tissue regeneration | [231] |
| TGF-β3 and BMP-2 | PCL-POEGMA poly (oligoethyleneglycol methacrylate) scaffolds | - | Enhanced osteochondral differentiation of human mesenchymal stromal cells | [232] |
| VEGF | Polylactide + alginate | - | Decent VEGF discharge rate, boosted neovascularization in the bone healing process, and preserved bioactivity | [233] |
| - | Gel/HA | Ascorbic acid β-glycerophosphate disodium salt hydrate |
Promoted osteoblast differentiation and induced bone regeneration | [234] |
| - | PCL/Gel/nanosilicate | Alendronate | Accelerated bone regeneration | [235] |