Figure 2.

HDAC inhibitors rescue RGCs by modulating the histone acetylation levels. HDAC families I, II, and III are known to upregulate significantly in glaucoma models [64]. Blocking HDAC activity using inhibitors offers significant neuroprotection, including enhanced RGC protection. HDAC activity inhibition reprograms the chromatin structure to a pro-translational configuration which occurs through modulation of factors such as p53, CREB-binding protein/p300 (CBP/p300), and the p300-CBP-associated factor (P/CAF), which facilitate neuroprotection, etc. [67,68]. Ac: acetyl group.