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. 2022 Aug 22;23(16):9489. doi: 10.3390/ijms23169489

Figure 2.

Figure 2

CDNF expression is upregulated after experimentally induced ER stress in mouse tissues in vivo. Increased expression of UPR genes in (A) brain, (B) kidney, and (C) liver tissues of mice injected with tunicamycin dissolved in dimethylsulfoxide (DMSO) and diluted in PBS in contrast to control (DMSO) + PBS-injected mice analyzed by RT-qPCR. n = 2–5 per group. (D) MANF mRNA and (E) protein levels and (F) CDNF mRNA and (G) protein levels in brain, kidney, and liver analyzed by RT-qPCR and ELISA from DMSO-injected control mice and tunicamycin-injected mice. n = 2–5 mice per group. Data are presented as mean ± SEM. Student’s t-test, * p < 0.05, ** p < 0.01, *** p < 0.001.