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Schematic drawing of the signaling transduction of EDA pathway. Secreted EDA binds to its receptor EDAR and forms a complex with the intracellular EDARADD, then recruits TAK1, TAB2, and TRAF6, induces IKK phosphorylation, and translocates NF-κB into the nucleus, followed by attaching with the BAF complex, and eventually facilitates specific gene transcription (*: gene mutations identified in HED patients).
