Figure 2.

The EDA pathway involved in the pathogenesis of HED, cancer, and NAFLD. Gene mutations in the EDA pathway lead to hypohidrotic ectodermal dysplasia (HED), with clinical symptoms including xerophthalmia, sweat gland dysplasia, hypodontia, and follicular dysplasia. EDA signaling is also involved in tumorigenesis and cancer progression of breast cancer, colorectal cancer, oral cancer, and melanoma. In addition, EDA, as a newly discovered hepatocyte factor, may be highly involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD).