Table 1.
Mean LDL-C and mean age in FH individuals with and without CVD in studies published before the introduction of statin treatment [23,24,25,26] or including non-treated individuals only [27] None of the participants had been treated with other cholesterol lowering drugs either.
| Authors | Number | LDL-C (mmol/L) | p | Age (Years) | p | |||
|---|---|---|---|---|---|---|---|---|
| CVD+ | CVD− | CVD+ | CVD− | CVD+ | CVD− | |||
| Yamashita et al., 1987 [23] Men Women |
23 11 |
19 13 |
7.65 8.10 |
7.09 7.53 |
ns ns |
51.1 56.8 |
45.9 52.5 |
ns ns |
| Seed et al., 1990 [24] | 54 | 61 | 8.1 | 8.2 | ns | 47.6 | 42.0 | <0.05 |
| Hill et al., 1991 [25] Men Women |
47 26 |
68 147 |
7.13 7.25 |
6.51 7.01 |
<0.05 ns |
48.2 54.7 |
45.3 49.7 |
ns ns |
| Tato et al., 1993 [26] | 32 | 59 | 8.14 | 7.68 | ns | 50.8 | 54.8 | ns |
| Jansen et al., 2004 [27] | 782 | 1618 | 7.45 # | 7.37 # | ns | 50.4 | 42.8 | <0.001 |
ns: not significant; # Measured after at least six weeks without statin treatment.